Interaction Scheme

Molecule

Lysine
D/L-Lys

Host

Cb7
CB7

c = 30.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 800.0 ± 60.0 M-1
Kd =
logKa = 2.9 ± 0.03
T 30.0 °C 303 K
Energy kJ mol-1 kcal mol-1
ΔG = -16.85 ± 0.19 -4.03 ± 0.05
ΔH = -17.1 ± 0.41 -4.09 ± 0.1
-TΔS = 0.8 ± 0.4 0.19 ± 0.1
J mol-1 K-1 cal mol-1 K-1
ΔS = -2.6 ± 1.3 -0.6 ± 0.3
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Isothermal Titration Calorimetry
Molecule: syringe
Partner: cell
Detailed information about the solvation.
Solvent System Buffer System 10 mM ammonium acetate pH-6.0
Solvents water 100.0 %
Additives Ammonium acetate 10.0 mM
Source of Concentration
Total concentration 10.0 mM
pH 6.0
Please find here information about the dataset this interaction is part of.
Citation:

W. M. Nau, V. D. Uzunova, A. Hennig, D. M. Bailey, SupraBank 2024, Supramolecular Tandem Enzyme Assays for Multiparameter Sensor Arrays and Enantiomeric Excess Determination of Amino Acids (dataset). https://doi.org/10.34804/supra.20210928260

Link: https://doi.org/10.34804/supra.20210928260
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

D. M. Bailey, A. Hennig, V. D. Uzunova, W. M. Nau, Chem. Eur. J. 2008, 14, 6069–6077.

Link: https://doi.org/10.1002/chem.200800463
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Binding Isotherm Simulations


The plot depicts the binding isotherm simulation of a 1:1 interaction of D/L-Lys (0.025 M) and CB7 (0 — 0.05 M).