Interaction Scheme

Molecule

L tryptophan
L-Trp

c = 20.0 µM

Host

Inverted cb7 2
Inverted CB[7]

c = 0.0 — 40.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 2.68⋅104 M-1
Kd =
logKa = 4.43
T 25.0 °C 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -25.28 -6.04
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 269.0 nm
𝛌em = 359.0 nm
Detailed information about the solvation.
Solvent System Buffer System 10 mM phosphate pH-7.0
Solvents water
Source of Concentration
Total concentration 10.0 mM
pH 7.0
Please find here information about the dataset this interaction is part of.
Citation:

Z. Gao, J. Kan, L. Chen, D. Bai, H. Wang, Z. Tao, X. Xiao, SupraBank 2024, Binding and Selectivity of Essential Amino Acid Guests to the Inverted Cucurbit[7]uril Host (dataset). https://doi.org/10.34804/supra.20210928153

Link: https://doi.org/10.34804/supra.20210928153
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

Z.-Z. Gao, J.-L. Kan, L.-X. Chen, D. Bai, H.-Y. Wang, Z. Tao, X. Xiao, ACS Omega 2017, 2, 5633–5640.

Link: https://doi.org/10.1021/acsomega.7b00429
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Binding Isotherm Simulations


The plot depicts the binding isotherm simulation of a 1:1 interaction of L-Trp (0.0007462686567164179 M) and Inverted CB[7] (0 — 0.0014925373134328358 M).