SupraBank - Multianalyte Sensing of Addictive Over-the-Counter (OTC) Drugs

Description:: A supramolecular sensor array composed of two fluorescent cucurbit[n]uril-type receptors (probe 1 and probe 2) displaying complementary selectivities was tested for its ability to detect and quantify drug-related amines. The fluorimetric titration of the individual probes showed highly variable and cross-reactive analyte-dependent changes in fluorescence. An excellent ability to recognize a variety of analytes was demonstrated in qualitative as well as quantitative assays. Importantly, a successful quantitative analysis of several analytes of interest was achieved in mixtures and in human urine. The throughput and sensitivity surpass those of the current state-of-the-art methods that usually require analyte solid-phase extraction (SPE). These results open up the opportunity for new applications of cucurbit[n]uril-type receptors in sensing and pave the way for the development of simple high-throughput assays for various drugs in the near future.

Views	Downloads	Citations
5606	0	0

Creators:: | | Tsuyoshi Minami; | | Nina A. Esipenko; | | Ali Akdeniz; | | Ben Zhang; | | Lyle Isaacs; | | Pavel Anzenbacher
Contributers:: | | Laura Grimm | DataManager

How can we help you?

Choose This is a comprehensive overview please explain what each part means.
Choose I currently do not really know what to do next, please give me some guidance.

Close Guide

Citation:	T. Minami, N. A. Esipenko, B. Zhang, L. Isaacs, P. Anzenbacher, A. Akdeniz, SupraBank 2024, Multianalyte Sensing of Addictive Over-the-Counter (OTC) Drugs (dataset). https://doi.org/10.34804/supra.2021092860
Link:	https://doi.org/10.34804/supra.2021092860
Export:	BibTex \| RIS \| EndNote

Citation:	T. Minami, N. A. Esipenko, A. Akdeniz, B. Zhang, L. Isaacs, P. Anzenbacher Jr., J. Am. Chem. Soc. 2013, 135, 15238–15243.
Link:	https://doi.org/10.1021/ja407722a
Export:	BibTex \| RIS \| EndNote \|