Interaction Scheme

Molecule

Sanguinarine
Sanguinarine

c = 0.59 µM

Host

Cb7
CB7

c = 0.0 — 160.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 1.40⋅106 ± M-1
Kd =
logKa = 6.15 ± 0.0
T 25.0 °C 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -35.08 ± 0.0 -8.38 ± 0.0
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 440.0 nm
𝛌em = 558.0 nm
IboundIfree = 17.7
Detailed information about the solvation.
Solvent System Complex Mixture
Solvents water
Additives hydrochloric acid
pH 4.0
Please find here information about the dataset this interaction is part of.
Citation:

Z. Miskolczy, L. Biczók, M. Megyesi, G. Tárkányi, R. Mizsei, SupraBank 2022, Inclusion complex formation of sanguinarinealkaloid with cucurbit[7]uril: inhibition of nucleophilic attack and photooxidation (dataset). https://doi.org/10.34804/supra.20210928132

Link: https://doi.org/10.34804/supra.20210928132
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

Z. Miskolczy, M. Megyesi, G. Tárkányi, R. Mizsei, L. Biczók, Org. Biomol. Chem. 2011, 9, 1061–1070.

Link: https://doi.org/10.1039/c0ob00666a
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Binding Isotherm Simulations


The plot depicts the binding isotherm simulation of a 1:1 interaction of Sanguinarine (1.4285714285714285e-05 M) and CB7 (0 — 2.857142857142857e-05 M).