Interaction

curated

Interaction Scheme

Molecule

Sanguinarine
Sanguinarine

c = 1.0 µM

Host

Cb6
CB6

c = 0.0 — 100.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 6730.0 ± M-1
Kd =
logKa = 3.83 ± 0.0
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -21.85 ± 0.0 -5.22 ± 0.0
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 328.0 nm
𝛌em = 552.0 nm
Ibound⁄Ifree = 2.1
Detailed information about the solvation.
Solvent System Buffer System 16 mM Britton–Robinson pH-1.8
Solvents water
Additives Phosphoric acid
acetic acid
BORIC ACID
Sodium hydroxide
Source of Concentration real
Total concentration 16.0 mM
pH 1.8
Please find here information about the dataset this interaction is part of.
Citation:

C. Li, L. Du, H. Zhang, SupraBank 2025, Study on the inclusion interaction of cucurbit[n]urils with sanguinarine by spectrofluorimetry and its analytical application (dataset). https://doi.org/10.34804/supra.20210928150

Link: https://doi.org/10.34804/supra.20210928150
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

C.-F. Li, L.-M. Du, H.-M. Zhang, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2010, 75, 912–917.

Link: https://doi.org/10.1016/j.saa.2009.12.036
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Sanguinarine (0.0029717682020802376 M) and CB6 (0 — 0.005943536404160475 M).