Interaction

curated

Interaction Scheme

Molecule

Tropicamide %28protonated%29
Tropicamide (protonated)

c = 25.0 µM

Host

Cb8
CB8

c = 0.0 — 40.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 4.00⋅106 ± 4.00⋅105 M-1
Kd =
logKa = 6.6 ± 0.04
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -37.68 ± 0.25 -9.01 ± 0.06
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Absorbance
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
pH 3.0
Please find here information about the dataset this interaction is part of.
Citation:

W. M. Nau, I. Ghosh, N. Saleh, M. A. Meetani, L. Al-Kaabi, SupraBank 2024, Effect of cucurbit[n]urils on tropicamide and potential application in ocular drug delivery (dataset). https://doi.org/10.34804/supra.20210928241

Link: https://doi.org/10.34804/supra.20210928241
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

N. Saleh, M. A. Meetani, L. Al-Kaabi, I. Ghosh, W. M. Nau, Supramolecular Chemistry 2011, 23, 650–656.

Link: https://doi.org/10.1080/10610278.2011.593631
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Tropicamide (protonated) (5.0e-06 M) and CB8 (0 — 1.0e-05 M).