Interaction Scheme

Molecule

Serotonin
Serotonin

c = 5.0 µM

Host

Beta cd
β-CD

c = 0.0 — 20000.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 53.2 ± 17.3 M-1
Kd =
logKa = 1.73 ± 0.15
T 25.0 °C 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -9.85 ± 0.84 -2.35 ± 0.2
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 300.0 nm
𝛌em = 334.0 nm
Detailed information about the solvation.
Solvent System Complex Mixture
Solvents water
Additives sodium chloride 150.0 mM
Sodium dihydrog... 20.0 mM
Disodium hydrog... 20.0 mM
pH 7.0
Please find here information about the dataset this interaction is part of.
Citation:

R. H. Bisby, S. W. Botchway, S. Dad, A. W. Parker, SupraBank 2024, Single- and multi-photon excited fluorescence from serotonin complexed with β-cyclodextrin (dataset). https://doi.org/10.34804/supra.20210928294

Link: https://doi.org/10.34804/supra.20210928294
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

R. H. Bisby, S. W. Botchway, S. Dad, A. W. Parker, Photochem. Photobiol. Sci. 2006, 5, 122–125.

Link: https://doi.org/10.1039/B508602G
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Binding Isotherm Simulations


The plot depicts the binding isotherm simulation of a 1:1 interaction of Serotonin (0.37593984962406013 M) and β-CD (0 — 0.7518796992481203 M).