Interaction Scheme

Molecule

Nacl
Sodium chloride

Host

12 crown 4
12-Crown-4

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 50.119 M-1
Kd =
logKa = 1.7
T 25.0 °C 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -9.7 -2.32
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Potentiometry
Detailed information about the solvation.
Solvent System Single Solvent
Solvent methanol
Please find here information about the dataset this interaction is part of.
Citation:

G. W. Gokel, W. M. Leevy, M. E. Weber, SupraBank 2024, Crown Ethers:  Sensors for Ions and Molecular Scaffolds for Materials and Biological Models (dataset). https://doi.org/10.34804/supra.20210928196

Link: https://doi.org/10.34804/supra.20210928196
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

G. W. Gokel, W. M. Leevy, M. E. Weber, Chem. Rev. 2004, 104, 2723–2750.

Link: https://doi.org/10.1021/cr020080k
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Binding Isotherm Simulations


The plot depicts the binding isotherm simulation of a 1:1 interaction of Sodium chloride (0.3990502603802949 M) and 12-Crown-4 (0 — 0.7981005207605898 M).