Interaction

curated

Interaction Scheme

Molecule

Lucigenin
Lucigenin

c = 1.1 µM

Host

Sulfocalix 5 arene
sCx5

c = 0.0 — 4.2 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 2.50⋅107 ± 3.00⋅106 M-1
Kd =
logKa = 7.4 ± 0.05
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -42.23 ± 0.3 -10.09 ± 0.07
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 460.0 nm
𝛌em = 505.0 nm
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
pH 7.0
Please find here information about the dataset this interaction is part of.
Citation:

D. Guo, Y. Liu, W. M. Nau, V. D. Uzunova, X. Su, SupraBank 2024, Operational calixarene-based fluorescent sensing systems for choline and acetylcholine and their application to enzymatic reactions (dataset). https://doi.org/10.34804/supra.2021092878

Link: https://doi.org/10.34804/supra.2021092878
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

D.-S. Guo, V. D. Uzunova, X. Su, Y. Liu, W. M. Nau, Chem. Sci. 2011, 2, 1722.

Link: https://doi.org/10.1039/C1SC00231G%20
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Lucigenin (8.0e-07 M) and sCx5 (0 — 1.6e-06 M).