Interaction

curated

Interaction Scheme

Molecule

Dansylcholine
Dansylcholine

c = 3.3 µM

Host

Scx8
sCx8

c = 0.0 — 19.5 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 3.30⋅105 M-1
Kd =
logKa = 5.52
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -31.5 -7.53
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 340.0 nm
𝛌em = 558.0 nm
Ibound⁄Ifree = 0.6
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
pH 6.9
Please find here information about the dataset this interaction is part of.
Citation:

T. Jin, SupraBank 2024, A New Fluorometric Method for the Detection of the Neurotransmitter Acetylcholine in Water Using a Dansylcholine Complex with p-Sulfonated Calix[8]arene - Journal of Inclusion Phenomena and Macrocyclic Chemistry (dataset). https://doi.org/10.34804/supra.20211007403

Link: https://doi.org/10.34804/supra.20211007403
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

T. Jin, Journal of Inclusion Phenomena and Macrocyclic Chemistry 2003, 45, 195–201.

Link: https://doi.org/10.1023/A:1024506714332
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Dansylcholine (6.0606060606060605e-05 M) and sCx8 (0 — 0.00012121212121212121 M).