Interaction

curated

Interaction Scheme

Molecule

L tyrosine
L-Tyr

Host

Cb7
CB7

c = 30.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 2.20⋅104 ± 3000.0 M-1
Kd =
logKa = 4.34 ± 0.06
T 30.0 °C ≈ 303 K
Energy kJ mol-1 kcal mol-1
ΔG = -25.2 ± 0.35 -6.02 ± 0.08
ΔH = -27.2 ± 2.5 -6.5 ± 0.6
-TΔS = 2.51 ± 2.1 0.6 ± 0.5
J mol-1 K-1 cal mol-1 K-1
ΔS = -8.3 ± 6.9 -2.0 ± 1.7
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Isothermal Titration Calorimetry
Molecule: syringe
Partner: cell
Detailed information about the solvation.
Solvent System Buffer System 10 mM ammonium acetate pH-6.0
Solvents water 100.0 %
Additives Ammonium acetate 10.0 mM
Source of Concentration
Total concentration 10.0 mM
pH 6.0
Please find here information about the dataset this interaction is part of.
Citation:

W. M. Nau, V. D. Uzunova, A. Hennig, D. M. Bailey, SupraBank 2025, Supramolecular Tandem Enzyme Assays for Multiparameter Sensor Arrays and Enantiomeric Excess Determination of Amino Acids (dataset). https://doi.org/10.34804/supra.20210928260

Link: https://doi.org/10.34804/supra.20210928260
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

D. M. Bailey, A. Hennig, V. D. Uzunova, W. M. Nau, Chem. Eur. J. 2008, 14, 6069–6077.

Link: https://doi.org/10.1002/chem.200800463
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of L-Tyr (0.0009090909090909091 M) and CB7 (0 — 0.0018181818181818182 M).