Interaction Scheme
Molecule
Oxaliplatin
c = 0.0 — 4500.0 µM
Host
CB7
c = 1000.0 µM
Binding Properties
| 𝜈 | Molecule 1 : 1 Host | ||
| Ka = | 2.30⋅105 | M-1 | |
| Kd = | |||
| logKa = | |||
| T | 25.0 °C | ||
| Energy | kJ mol-1 | kcal mol-1 | |||
|---|---|---|---|---|---|
| ΔG | = | -30.6 | -7.31 | ||
| ΔH | = | -26.36 | ± 0.42 | -6.3 | ± 0.1 |
| -TΔS | = | -4.11 | -0.98 | ||
| J mol-1 K-1 | cal mol-1 K-1 | ||||
| ΔS | = | 13.8 | 3.3 | ||
These are the specifications of the determination of the experimental results.
| Detection Method: | Direct | ||
| Assay Type: | Direct Binding Assay | ||
| Technique: | Isothermal Titration Calorimetry | ||
| Molecule: | syringe | ||
| Partner: | cell | ||
Detailed information about the solvation.
| Solvent System | Buffer System | Tris pH-7.2 |
| Solvents | water | |
| Additives | Trometamol | |
| hydrochloric acid | ||
| Source of Concentration | estimated | |
| Total concentration | 1.0 mM | |
| pH | 7.2 |
Please find here information about the dataset this interaction is part of.
| Citation: |
Y. Jin Jeon, S. Kim, Y. Ho Ko, S. Sakamoto, K. Yamaguchi, K. Kim, SupraBank 2024, Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug (dataset). https://doi.org/10.34804/supra.2021092861 |
| Link: | https://doi.org/10.34804/supra.2021092861 |
| Export: | BibTex | RIS | EndNote |
Please find here information about the scholarly article describing the results derived from that data.
| Citation: |
Y. Jin Jeon, S.-Y. Kim, Y. Ho Ko, S. Sakamoto, K. Yamaguchi, K. Kim, Org. Biomol. Chem. 2005, 3, 2122. |
| Link: | https://doi.org/10.1039/B504487A |
| Export: | BibTex | RIS | EndNote | |
Binding Isotherm Simulations
The plot depicts the binding isotherm simulation of a 1:1 interaction of Oxaliplatin (8.695652173913044e-05 M) and CB7 (0 — 0.00017391304347826088 M).
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