Interaction Scheme
Molecule
Lucigenin
c = 10.0 µM
Host
sCx4-12C
c = 0.0 — 21.0 µM
Binding Properties
| 𝜈 | Molecule 1 : 1 Host | ||
| Ka = | 8.10⋅105 | ± 4.00⋅105 | M-1 |
| Kd = | |||
| logKa = | |||
| T | 25.0 °C | ||
| Energy | kJ mol-1 | kcal mol-1 | |||
|---|---|---|---|---|---|
| ΔG | = | -33.73 | ± 1.34 | -8.06 | ± 0.32 |
These are the specifications of the determination of the experimental results.
| Detection Method: | Direct | |||
| Assay Type: | Direct Binding Assay | |||
| Technique: | Fluorescence | |||
| 𝛌ex | = | 420.0 nm | ||
| 𝛌em | = | 510.0 nm | ||
Detailed information about the solvation.
| Solvent System | Buffer System | 10 mM phosphate pH-7.4 |
| Solvents | water | 100.0 % |
| Additives | Disodium phosph... | 7.5 mM |
| Sodium dihydro... | 2.5 mM | |
| Source of Concentration | ||
| Total concentration | 10.0 mM | |
| pH | 7.4 |
Please find here information about the dataset this interaction is part of.
| Citation: |
X. Hu, D. Guo, Y. Pan, H. Tian, H. Zhao, X. Yang, SupraBank 2025, Inhibition of insulin fibrillation by amphiphilic sulfonatocalixarene (dataset). https://doi.org/10.34804/supra.20210928362 |
| Link: | https://doi.org/10.34804/supra.20210928362 |
| Export: | BibTex | RIS | EndNote |
Please find here information about the scholarly article describing the results derived from that data.
| Citation: |
H. Zhao, X.-H. Yang, Y.-C. Pan, H.-W. Tian, X.-Y. Hu, D.-S. Guo, Chinese Chemical Letters 2020, 31, 1873–1876. |
| Link: | https://doi.org/10.1016/j.cclet.2020.01.042 |
| Export: | BibTex | RIS | EndNote |
Binding Isotherm Simulations
The plot depicts the binding isotherm simulation of a 1:1 interaction of Lucigenin (2.4691358024691357e-05 M) and sCx4-12C (0 — 4.938271604938271e-05 M).
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