Interaction Scheme
Molecule
5, 10, 15, 20-Tetrakis-(4-sulfonatophenyl)-porp...
c = 0.0 — 1.9 µM
Host
gCx5-6C
c = 0.5 µM
Indicator
Fluorescein
c = 0.5 µM
Binding Properties
| 𝜈 | Molecule 1 : 1 Host | ||
| Ka = | 1.10⋅108 | ± 3.00⋅107 | M-1 |
| Kd = | |||
| logKa = | |||
| T | 25.0 °C | ||
| Energy | kJ mol-1 | kcal mol-1 | |||
|---|---|---|---|---|---|
| ΔG | = | -45.9 | ± 0.69 | -10.97 | ± 0.16 |
These are the specifications of the determination of the experimental results.
| Detection Method: | Competitive | |||
| Assay Type: | Competitive Binding Assay | |||
| Technique: | Fluorescence | |||
| 𝛌ex | = | 500.0 nm | ||
| 𝛌em | = | 512.0 nm | ||
Detailed information about the solvation.
| Solvent System | Buffer System | 10 mM HEPES pH-7.4 |
| Solvents | water | 100.0 % |
| Additives | Hepes | 10.0 mM |
| Source of Concentration | ||
| Total concentration | 10.0 mM | |
| pH | 7.4 |
Please find here information about the dataset this interaction is part of.
| Citation: |
J. Gao, F. Chen, D. Guo, Z. Zheng, W. Geng, J. Li, X. Duan, D. Ding, SupraBank 2024, Biomarker Displacement Activation: A General Host–Guest Strategy for Targeted Phototheranostics in Vivo (dataset). https://doi.org/10.34804/supra.20210928231 |
| Link: | https://doi.org/10.34804/supra.20210928231 |
| Export: | BibTex | RIS | EndNote |
Please find here information about the scholarly article describing the results derived from that data.
| Citation: |
J. Gao, J. Li, W.-C. Geng, F.-Y. Chen, X. Duan, Z. Zheng, D. Ding, D.-S. Guo, J. Am. Chem. Soc. 2018, 140, 4945–4953. |
| Link: | https://doi.org/10.1021/jacs.8b02331 |
| Export: | BibTex | RIS | EndNote | |
Binding Isotherm Simulations
The plot depicts the binding isotherm simulation of a 1:1 interaction of 5, 10, 15, 20-Tetrakis-(4-sulfonatophenyl)-porphyrin (1.8181818181818183e-07 M) and gCx5-6C (0 — 3.6363636363636366e-07 M).
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