Interaction

curated

Interaction Scheme

Molecule

Untitled
paclitaxel

c = 0.0 — 3.5 µM

Host

Acx4 bz cooh
aCx4-Bz-COOH

c = 0.3 µM

Indicator

Rhodamine b
Rhodamine B

c = 0.3 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 1.60⋅106 ± 1.00⋅105 M-1
Kd =
logKa = 6.2 ± 0.03
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -35.41 ± 0.16 -8.46 ± 0.04
These are the specifications of the determination of the experimental results.
Detection Method: Competitive
Assay Type: Competitive Binding Assay
Technique: Fluorescence
𝛌ex = 554.0 nm
𝛌em = 575.0 nm
Detailed information about the solvation.
Solvent System Buffer System
Source of Concentration
Please find here information about the dataset this interaction is part of.
Citation:

D. Guo, T. Zhang, Z. Zhang, Y. Yue, X. Hu, F. Huang, L. Shi, Y. Liu, SupraBank 2024, A General Hypoxia‐Responsive Molecular Container for Tumor‐Targeted Therapy (dataset). https://doi.org/10.34804/supra.2021092885

Link: https://doi.org/10.34804/supra.2021092885
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

T. X. Zhang, Z. Z. Zhang, Y. X. Yue, X. Y. Hu, F. Huang, L. Shi, Y. Liu, D. S. Guo, Adv. Mater. 2020, 32, 1908435.

Link: https://doi.org/10.1002/adma.201908435
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of paclitaxel (1.25e-05 M) and aCx4-Bz-COOH (0 — 2.5e-05 M).