Interaction

curated

Interaction Scheme

Molecule

Chlorpromazine hydrochloride
Chlorpromazine hydrochloride

Host

Gamma cd
γ-CD

c = 10200.0 µM

Binding Properties

𝜈 Molecule 2 : 1 Host
Ka = 3970.0 ± 140.0 M-2
Kd =
logKa = 3.6 ± 0.02
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -20.54 ± 0.09 -4.91 ± 0.02
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Potentiometry
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
Please find here information about the dataset this interaction is part of.
Citation:

N. Takisawa, K. Shirahama, I. Tanaka, SupraBank 2024, Interactions of amphiphilic drugs with?-,?-, and?-cyclodextrins (dataset). https://doi.org/10.34804/supra.2021092846

Link: https://doi.org/10.34804/supra.2021092846
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

N. Takisawa, K. Shirahama, I. Tanaka, Colloid Polym Sci 1993, 271, 499–506.

Link: https://doi.org/10.1007/BF00657395
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Chlorpromazine hydrochloride (0.005037783375314861 M) and γ-CD (0 — 0.010075566750629723 M).