Interaction

curated

Interaction Scheme

Molecule

Untitled
dicyclomine

Host

Alpha cd
α-CD

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 280.0 ± 30.0 M-1
Kd =
logKa = 2.45 ± 0.05
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -13.97 ± 0.27 -3.34 ± 0.06
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Potentiometry
Detailed information about the solvation.
Solvent System Complex Mixture
Solvents water
water
Additives sodium chloride 10.0 mM
Please find here information about the dataset this interaction is part of.
Citation:

N. Takisawa, D. G. Hall, E. Wyn-Jones, P. Brown, SupraBank 2025, The construction and characteristics of drug-selective electrodes. Applications for the determination of complexation constants of inclusion complexes with α- and β-cyclodextrins including a kinetic study (dataset). https://doi.org/10.34804/supra.20210928323

Link: https://doi.org/10.34804/supra.20210928323
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

N. Takisawa, D. G. Hall, E. Wyn-Jones, P. Brown, J. Chem. Soc., Faraday Trans. 1 1988, 84, 3059.

Link: https://doi.org/10.1039/f19888403059
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of dicyclomine (0.07142857142857142 M) and α-CD (0 — 0.14285714285714285 M).