Interaction Scheme
Molecule
IR780
c = 2.0 µM
Host
Cx4-NH2
c = 0.0 — 50.7 µM
Binding Properties
| 𝜈 | Molecule 1 : 1 Host | ||
| Ka = | 2.30⋅104 | ± 3000.0 | M-1 |
| Kd = | |||
| logKa = | |||
| T | 25.0 °C | ||
| Energy | kJ mol-1 | kcal mol-1 | |||
|---|---|---|---|---|---|
| ΔG | = | -24.9 | ± 0.33 | -5.95 | ± 0.08 |
These are the specifications of the determination of the experimental results.
| Detection Method: | Direct | |||
| Assay Type: | Direct Binding Assay | |||
| Technique: | Fluorescence | |||
| 𝛌ex | = | 704.0 nm | ||
| 𝛌em | = | 790.0 nm | ||
Detailed information about the solvation.
| Solvent System | Buffer System | 10 mM PBS pH-7.4 |
| Solvents | water | |
| Additives | sodium chloride | 136.99 mM |
| Disodium hydrog... | 6.13 mM | |
| Sodium dihydrog... | 5.03 mM | |
| potassium chloride | 2.7 mM | |
| Source of Concentration | estimated | |
| Total concentration | 10.0 mM | |
| pH | 7.4 |
Please find here information about the dataset this interaction is part of.
| Citation: |
D. Guo, F. Huang, Y. Kong, F. Yang, T. Zhang, H. Li, X. Hou, Y. Yue, M. R. Shah, J. Liu, SupraBank 2024, A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy (dataset). https://doi.org/10.34804/supra.20211124412 |
| Link: | https://doi.org/10.34804/supra.20211124412 |
| Export: | BibTex | RIS | EndNote |
Please find here information about the scholarly article describing the results derived from that data.
| Citation: |
T.-X. Zhang, X. Hou, Y. Kong, F. Yang, Y.-X. Yue, M. R. Shah, H.-B. Li, F. Huang, J. Liu, D.-S. Guo, Theranostics 2022, 12, 396–409. |
| Link: | https://doi.org/10.7150/thno.67036 |
| Export: | BibTex | RIS | EndNote |
Binding Isotherm Simulations
The plot depicts the binding isotherm simulation of a 1:1 interaction of IR780 (0.0008695652173913044 M) and Cx4-NH2 (0 — 0.0017391304347826088 M).
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