Interaction Scheme



c ≈ 0.0 — 120.0 µM



c = 50.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka < 1.00⋅104 M-1
Kd <
logKa < 4.0
T 25.0 °C 298 K
Energy kJ mol-1 kcal mol-1
ΔG > -22.83 -5.46
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Isothermal Titration Calorimetry
Instrument: MicroCal VP-ITC
VCell = 1400.0 𝜇L
VSyringe = 350.0 𝜇L
cmolecule = 600.0 𝜇M    syringe
cpartner = 50.0 𝜇M    cell
Detailed information about the solvation.
Solvent System Buffer System 10 mM phosphate pH-7
Solvents water
Additives Sodium dihydrog...
Disodium hydrog...
Source of Concentration
Total concentration 10.0 mM
pH 7.0
Please find here information about the dataset this interaction is part of.

F. Biedermann, N. Zhao, L. Liu, O. Scherman, SupraBank 2024, Binding Studies on CB[6] with a Series of 1-Alkyl-3-methylimidazolium Ionic Liquids in an Aqueous System (dataset).

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Please find here information about the scholarly article describing the results derived from that data.

N. Zhao, L. Liu, F. Biedermann, O. A. Scherman, Chem. Asian J. 2010, 5, 530–537.

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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of [C3mim]Br (0.002 M) and CB6 (0 — 0.004 M).