Interaction

uncurated

Interaction Scheme

Molecule

Mvcp
MVCP

Host

Cb8
CB8

Indicator

Memantine
Memantine

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 9.70⋅1012 ± 1.29⋅1012 M-1
Kd =
logKa = 12.99 ± 0.06
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -74.13 ± 0.33 -17.72 ± 0.08
These are the specifications of the determination of the experimental results.
Detection Method: Competitive
Assay Type: Competitive Binding Assay
Technique: Nuclear Magnetic Resonance
Nucleus H-1
Detailed information about the solvation.
Solvent System Single Solvent
Solvent Deuterium Oxide
Please find here information about the dataset this interaction is part of.
Citation:

L. Grimm, SupraBank 2024, Fluorescent Paracyclophanes: Unveiling Ultra-strong Binding with Cucurbit[8]uril in Aqueous Environments (dataset). https://doi.org/10.34804/supra.20240313527

Link: https://doi.org/10.34804/supra.20240313527
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

Link: https://suprabank.org/datasets/527

Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of MVCP (2.061855670103093e-12 M) and CB8 (0 — 4.123711340206186e-12 M).