Interaction

uncurated

Interaction Scheme

Molecule

Methyl pyridinium paracyclophane iodide
MPCP

c = 0.0 — 3.2 µM

Host

Cb8
CB8

c = 1.45 µM

Indicator

Memantine
Memantine

c = 1.13 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 3.29⋅1013 ± 9.50⋅1012 M-1
Kd =
logKa = 13.52 ± 0.13
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -77.16 ± 0.74 -18.44 ± 0.18
These are the specifications of the determination of the experimental results.
Detection Method: Competitive
Assay Type: Competitive Binding Assay
Technique: Fluorescence
𝛌ex = 383.0 nm
𝛌em = 520.0 nm
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
Please find here information about the dataset this interaction is part of.
Citation:

L. Grimm, SupraBank 2024, Fluorescent Paracyclophanes: Unveiling Ultra-strong Binding with Cucurbit[8]uril in Aqueous Environments (dataset). https://doi.org/10.34804/supra.20240313527

Link: https://doi.org/10.34804/supra.20240313527
Export: BibTex | RIS | EndNote
Please find here information about the scholarly article describing the results derived from that data.
Citation:

Link: https://suprabank.org/datasets/527

Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of MPCP (6.079027355623101e-13 M) and CB8 (0 — 1.2158054711246201e-12 M).