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DOI:
https://doi.org/10.34804/supra.20210928109 Cc Cc by 4.0

Title:
Synthesis of New Trisulfonated Calix[4]arenes Functionalized at the Upper Rim, and Their Complexation with the Trimethyllysine Epigenetic Mark

https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/orlef7/2012/orlef7.2012.14.issue-6/ol300243b/production/images/large/ol-2012-00243b_0005.jpeg

Description:
A synthetic route to produce a new family of trisulfonated calix[4]arenes bearing a single group, selectively introduced, that lines the binding pocket is reported. Ten examples, including new sulfonamide and biphenyl-substituted hosts, each with additional binding elements, demonstrate the tuning of guest affinities and selectivities. NMR titrations in phosphate-buffered water show that one of the new hosts binds to the modified amino acid trimethyllysine with the highest affinity and selectivity observed to date.

Citation:

K. D. Daze, F. Hof, M. C. F. Ma, F. Pineux, SupraBank 2024, Synthesis of New Trisulfonated Calix[4]arenes Functionalized at the Upper Rim, and Their Complexation with the Trimethyllysine Epigenetic Mark (dataset). https://doi.org/10.34804/supra.20210928109

Link: https://doi.org/10.34804/supra.20210928109
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Citation:

K. D. Daze, M. C. F. Ma, F. Pineux, F. Hof, Org. Lett. 2012, 14, 1512–1515.

Link: https://doi.org/10.1021/ol300243b
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Creators:
Orcidid | Ror | Kevin D. Daze
Orcidid | Ror | Manuel C. F. Ma
Orcidid | Ror | Florent Pineux
Orcidid | Ror | Fraser Hof

Contributers:
Orcidid | Ror | Mary Maguire | DataManager

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