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DOI:
https://doi.org/10.34804/supra.20210928129 Cc Cc by 4.0
Title:
A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy-entropy compensation
https://www.pnas.org/content/104/52/20737/F1.large.jpg
Description:
The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution. The equilibrium association constant for this host-guest pair is 3 × 1015 M−1 ( K d = 3 × 10−16 M), equivalent to that exhibited by the avidin–biotin pair. Although purely synthetic systems with larger association constants have been reported, the present one is unique because it does not rely on polyvalency. Instead, it achieves its extreme affinity by overcoming the compensatory enthalpy–entropy relationship usually observed in supramolecular complexes. Its disproportionately low entropic cost is traced to extensive host desolvation and to the rigidity of both the host and the guest.
Citation:

M. V. Rekharsky, T. Mori, C. Yang, Y. H. Ko, N. Selvapalam, H. Kim, D. Sobransingh, A. E. Kaifer, S. Liu, L. Isaacs, W. Chen, S. Moghaddam, M. K. Gilson, K. Kim, Y. Inoue, SupraBank 2024, A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy-entropy compensation (dataset). https://doi.org/10.34804/supra.20210928129

Link: https://doi.org/10.34804/supra.20210928129
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Citation:

M. V. Rekharsky, T. Mori, C. Yang, Y. H. Ko, N. Selvapalam, H. Kim, D. Sobransingh, A. E. Kaifer, S. Liu, L. Isaacs, et al., Proceedings of the National Academy of Sciences 2007, 104, 20737–20742.

Link: https://doi.org/10.1073/pnas.0706407105
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Creators:
Orcidid | Ror | M. V. Rekharsky
Orcidid | Ror | T. Mori
Orcidid | Ror | C. Yang
Orcidid | Ror | Y. H. Ko
Orcidid | Ror | N. Selvapalam
Orcidid | Ror | H. Kim
Orcidid | Ror | D. Sobransingh
Orcidid | Ror | A. E. Kaifer
Orcidid | Ror | S. Liu
Orcidid | Ror | L. Isaacs
Orcidid | Ror | W. Chen
Orcidid | Ror | S. Moghaddam
Orcidid | Ror | M. K. Gilson
Orcidid | Ror | K. Kim
Orcidid | Ror | Y. Inoue
Contributers:
Orcidid | Ror | Laura Grimm | DataManager

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