Dataset curated

DOI:
https://doi.org/10.34804/supra.20210928130 Cc Cc by 4.0

Title:
Cucurbit[7]uril host−guest complexations of steroidal neuromuscular blocking agents in aqueous solution

https://cdnsciencepub.com/na101/home/literatum/publisher/nrc/journals/content/cjc/2014/cjc.2014.9203/cjc-2013-0490/20140318/images/cjc-2013-0490con.tif

Description:
The complexations of three steroidal neuromuscular blocking agents, rocuronium, vecuronium, and pancuronium, by the cucurbit[7]uril host molecule have been investigated in aqueous solution using 1H NMR spectroscopy and ESI mass spectrometry. The CB[7] binds to each of the two terminal cationic N-heterocyclic groups by means of ion-dipole interactions and hydrophobic effects, with stability constants in the order of vecuronium > pancuronium > rocuronium. This trend is different from those observed for the anionic substituted γ-cyclodextrin (Sugammadex), currently employed as a neuromuscular blockade reversal agent, and an acylic glycoluril tetramer (Calabadion), recently reported to reverse both steroidal and benzylisoquinolium neuromuscular blocking agents in rats.

Citation:

D. H. Macartney, M. A. Gamal-Eldin, SupraBank 2024, Cucurbit[7]uril host−guest complexations of steroidal neuromuscular blocking agents in aqueous solution (dataset). https://doi.org/10.34804/supra.20210928130

Link: https://doi.org/10.34804/supra.20210928130
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Citation:

M. A. Gamal-Eldin, D. H. Macartney, Can. J. Chem. 2014, 92, 243–249.

Link: https://doi.org/10.1139/cjc-2013-0490
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Creators:
Orcidid | Ror | Mona A. Gamal-Eldin
Orcidid | Ror | Donal H. Macartney

Contributers:
Orcidid | Ror | Katharina Wendler | DataManager

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