SupraBank - Recognition-Mediated Light-Up of Thiazole Orange with Cucurbit[8]uril: Exchange and Release by Chemical Stimuli

DOI:: https://doi.org/10.34804/supra.2021092814
Title:: Recognition-Mediated Light-Up of Thiazole Orange with Cucurbit[8]uril: Exchange and Release by Chemical Stimuli

Description:: This article reports a convenient supramolecular strategy to construct fluorescent photoswitchable molecular assemblies between a macrocyclic host, cucurbit[8]uril (CB8), and a fluorogenic dye, thiazole orange (TO). The interaction mechanism and the stable stoichiometric host–guest arrangements have been claimed on the basis of the optical absorption, steady-state and time-resolved fluorescence lifetime and anisotropy measurements, and also the geometry optimization studies. The CB8 recognized TO in its 2:2 stoichiometry exhibited spectacular fluorescence enhancement of the order of 1700 fold, which is the largest directly determined value so far reported for a dye in an organic macrocyclic system. This prospective 2CB8:2TO assembly responded to selected chemical stimuli such as metal ions, adamantylamine, and tryptophan, providing different dissociation mechanisms and demonstrating a controlled exchange and release action desired with such noncovalently linked assemblies. Positively, considering the aqueous solubility and biocompatibility of the host–guest constituents, this methodology can evolve into a general approach to deliver and operate intracellularly functional molecular components under chemical/thermal/optical trigger control, especially for therapeutic applications.

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Creators:: | | Jyotirmayee Mohanty; | | Neha Thakur; | | Sharmistha Dutta Choudhury; | | Nilotpal Barooah; | | Haridas Pal; | | Achikanath C. Bhasikuttan
Contributers:: | | Meenakshi Shinde | DataManager

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Citation:	J. Mohanty, N. Thakur, S. Dutta Choudhury, N. Barooah, H. Pal, A. C. Bhasikuttan, SupraBank 2024, Recognition-Mediated Light-Up of Thiazole Orange with Cucurbit[8]uril: Exchange and Release by Chemical Stimuli (dataset). https://doi.org/10.34804/supra.2021092814
Link:	https://doi.org/10.34804/supra.2021092814
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Citation:	J. Mohanty, N. Thakur, S. Dutta Choudhury, N. Barooah, H. Pal, A. C. Bhasikuttan, J. Phys. Chem. B 2011, 116, 130–135.
Link:	https://doi.org/10.1021/jp210432t%20
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