Dataset curated

DOI:
https://doi.org/10.34804/supra.20210928219 Cc Cc by 4.0
Title:
Highly Effective Binding of Viologens by p-Sulfonatocalixarenes for the Treatment of Viologen Poisoning
https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/jmcmar/2009/jmcmar.2009.52.issue-20/jm900811z/production/images/large/jm-2009-00811z_0012.jpeg
Description:
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic protocol for the treatment of viologen poisoning. The mechanism of this new protocol is based on host−guest chemistry and involves the effective inhibition of viologen toxicity by the complexation of p-sulfonatocalix[n]arenes. NMR, ITC, and X-ray crystallography studies indicated that p-sulfonatocalix[n]arenes could form highly stable complexes with viologens. Electrochemical results showed that the highly effective binding could induce the reduction potentials of viologens to shift to more negative values. Further studies in mice showed that the ingestion of p-sulfonatocalix[n]arenes significantly decreased the mortality rate of viologen-poisoned mice with lung and liver protection. As a result, p-sulfonatocalix[n]arenes may have potential application in the clinical treatment of viologen poisoning.
Citation:

D. Guo, Y. Liu, K. Wang, H. Zhang, D. Li, X. Zheng, SupraBank 2024, Highly Effective Binding of Viologens by p-Sulfonatocalixarenes for the Treatment of Viologen Poisoning (dataset). https://doi.org/10.34804/supra.20210928219

Link: https://doi.org/10.34804/supra.20210928219
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Citation:

K. Wang, D.-S. Guo, H.-Q. Zhang, D. Li, X.-L. Zheng, Y. Liu, J. Med. Chem. 2009, 52, 6402–6412.

Link: https://doi.org/10.1021/jm900811z
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Creators:
Orcidid | Ror | Kui Wang
Orcidid | Ror | Dong-Sheng Guo
Orcidid | Ror | Hong-Qing Zhang
Orcidid | Ror | Dong Li
Orcidid | Ror | Xi-Long Zheng
Orcidid | Ror | Yu Liu
Contributers:
Orcidid | Ror | Yu-Chen Pan | DataManager

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