Dataset curated
- DOI:
- https://doi.org/10.34804/supra.20211020406
- Title:
- A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host
- Description:
- Superior to current clinically used reversal agents in terms of efficacy and side effects: The formation of a high-affinity host–guest binary complex (association constant Ka: ca. 107 M−1) between the aminosteroidal guest molecule rocuronium bromide, the most widely used neuromuscular blocking agent in surgery, and a cyclodextrin-based synthetic host molecule (see X-ray crystal structure) results in reversal of the neuromuscular blockade induced by rocuronium bromide.
| Citation: |
A. Bom, M. Bradley, K. Cameron, J. K. Clark, J. van Egmond, H. Feilden, E. J. MacLean, A. W. Muir, R. Palin, D. C. Rees, M. Zhang, SupraBank 2024, A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host (dataset). https://doi.org/10.34804/supra.20211020406 |
| Link: | https://doi.org/10.34804/supra.20211020406 |
| Export: | BibTex | RIS | EndNote |
| Views | Downloads | Citations |
|---|---|---|
| 1399 | 0 | 0 |
| Citation: |
A. Bom, M. Bradley, K. Cameron, J. K. Clark, J. van Egmond, H. Feilden, E. J. MacLean, A. W. Muir, R. Palin, D. C. Rees, et al., Angew. Chem. Int. Ed. 2002, 41, 265. |
| Link: | https://doi.org/10.1002/1521-3773(20020118)41:2%3C265::AID-ANIE265%3E3.0.CO;2-Q |
| Export: | BibTex | RIS | EndNote |
- Creators:
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Anton Bom
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Mark Bradley
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Ken Cameron
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John K. Clark
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Jan van Egmond
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Helen Feilden
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Elizabeth J. MacLean
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Alan W. Muir
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Ronald Palin
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David C. Rees
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Ming-Qiang Zhang
- Contributers:
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Amrutha Prabodh
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DataManager
- Subjects:
- catalysis general chemistry
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