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DOI:
https://doi.org/10.34804/supra.20220628440 Cc Cc by 4.0
Title:
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium
https://www.pnas.org/content/111/14/E1402/F1.large.jpg
Description:
Significance Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.
Citation:

M. M. Nociari, G. L. Lehmann, A. E. Perez Bay, R. A. Radu, Z. Jiang, S. Goicochea, R. Schreiner, J. D. Warren, J. Shan, S. Adam de Beaumais, M. Ménand, M. Sollogoub, F. R. Maxfield, E. Rodriguez-Boulan, SupraBank 2026, Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium (dataset). https://doi.org/10.34804/supra.20220628440

Link: https://doi.org/10.34804/supra.20220628440
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Citation:

M. M. Nociari, G. L. Lehmann, A. E. Perez Bay, R. A. Radu, Z. Jiang, S. Goicochea, R. Schreiner, J. D. Warren, J. Shan, S. Adam de Beaumais, et al., Proceedings of the National Academy of Sciences 2014, 111, E1402–E1408.

Link: https://doi.org/10.1073/pnas.1400530111
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Creators:
Orcidid | Ror | Marcelo M. Nociari
Orcidid | Ror | Guillermo L. Lehmann
Orcidid | Ror | Andres E. Perez Bay
Orcidid | Ror | Roxana A. Radu
Orcidid | Ror | Zhichun Jiang
Orcidid | Ror | Shelby Goicochea
Orcidid | Ror | Ryan Schreiner
Orcidid | Ror | J. David Warren
Orcidid | Ror | Jufang Shan
Orcidid | Ror | Ségolène Adam de Beaumais
Orcidid | Ror | Mickaël Ménand
Orcidid | Ror | Matthieu Sollogoub
Orcidid | Ror | Frederick R. Maxfield
Orcidid | Ror | Enrique Rodriguez-Boulan
Contributers:
Orcidid | Ror | Nilima Manoj Kumar | DataManager
Subjects:
multidisciplinary

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