SupraBank - Dressings Loaded with Cyclodextrin–Hamamelitannin Complexes Increase <i>Staphylococcus aureus</i> Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities

DOI:: https://doi.org/10.34804/supra.20240328543
Title:: Dressings Loaded with Cyclodextrin–Hamamelitannin Complexes Increase <i>Staphylococcus aureus</i> Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities

Description:: Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl‐β‐cyclodextrin‐functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected wounds. image

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Creators:: | | Gilles Brackman; | | Maria José Garcia‐Fernandez; | | Joke Lenoir; | | Laurens De Meyer; | | Jean‐Paul Remon; | | Thomas De Beer; | | Angel Concheiro; | | Carmen Alvarez‐Lorenzo; | | Tom Coenye
Contributers:: | | Nilima Manoj Kumar | DataManager
Subjects:: materials chemistry polymers and plastics biomaterials bioengineering biotechnology

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Citation:	G. Brackman, J. Lenoir, L. De Meyer, T. De Beer, A. Concheiro, T. Coenye, M. J. Garcia‐Fernandez, J. Remon, C. Alvarez‐Lorenzo, SupraBank 2024, Dressings Loaded with Cyclodextrin–Hamamelitannin Complexes Increase Staphylococcus aureus* Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities* (dataset). https://doi.org/10.34804/supra.20240328543
Link:	https://doi.org/10.34804/supra.20240328543
Export:	BibTex \| RIS \| EndNote

Citation:	G. Brackman, M. J. Garcia-Fernandez, J. Lenoir, L. De Meyer, J.-P. Remon, T. De Beer, A. Concheiro, C. Alvarez-Lorenzo, T. Coenye, Macromol. Biosci. 2016, 16, 859–869.
Link:	https://doi.org/10.1002/mabi.201500437
Export:	BibTex \| RIS \| EndNote