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DOI:
https://doi.org/10.34804/supra.2021092898 Cc Cc by 4.0
Title:
Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations
https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-50/ja209266x/production/images/large/ja-2011-09266x_0012.jpeg
Description:
The binding dynamics of R-(+)-2-naphthyl-1-ethylammonium cation (NpH+) with cucurbit[7]uril (CB[7]) was investigated. Competitive binding with Na+ or H3O+ cations enabled the reaction to be slowed down sufficiently for the kinetics to be studied by fluorescence stopped-flow experiments. The binding of two Na+ cations to CB[7], i.e., CB[7]·Na+ (K01 = 130 ± 10 M–1) and Na+·CB[7]·Na+ (K02 = 21 ± 2 M–1), was derived from the analysis of binding isotherms and the kinetic studies. NpH+ binds only to free CB[7] ((1.06 ± 0.05) × 107 M–1), and the association rate constant of (6.3 ± 0.3) × 108 M–1 s–1 is 1 order of magnitude lower than that for a diffusion-controlled process and much higher than the association rate constant previously determined for other CB[n] systems. The high equilibrium constant for the NpH+@CB[7] complex is a consequence of the slow dissociation rate constant of 55 s–1. The kinetics results showed that formation of a complex between a positively charged guest with CB[n] can occur at a rate close to the diffusion-controlled limit with no detection of a stable exclusion complex.
Citation:

K. Kim, H. Tang, C. Bohne, Y. H. Ko, D. Fuentealba, N. Selvapalam, SupraBank 2024, Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations (dataset). https://doi.org/10.34804/supra.2021092898

Link: https://doi.org/10.34804/supra.2021092898
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Citation:

H. Tang, D. Fuentealba, Y. H. Ko, N. Selvapalam, K. Kim, C. Bohne, J. Am. Chem. Soc. 2011, 133, 20623–20633.

Link: https://doi.org/10.1021/ja209266x
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Creators:
Orcidid | Ror | Hao Tang
Orcidid | Ror | Denis Fuentealba
Orcidid | Ror | Young Ho Ko
Orcidid | Ror | Narayanan Selvapalam
Orcidid | Ror | Kimoon Kim
Orcidid | Ror | Cornelia Bohne
Contributers:
Orcidid | Ror | Rui Kang | DataManager

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