Interaction

curated

Interaction Scheme

Molecule

Thiazole orange
Thiazole orange

c = 3.0 µM

Host

Cb8
CB8

c = 0.0 — 42.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 6.00⋅1011 M-1
Kd =
logKa = 11.78
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -67.23 -16.07
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 465.0 nm
𝛌em = 605.0 nm
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
pH 6.9
Please find here information about the dataset this interaction is part of.
Citation:

J. Mohanty, N. Thakur, S. Dutta Choudhury, N. Barooah, H. Pal, A. C. Bhasikuttan, SupraBank 2025, Recognition-Mediated Light-Up of Thiazole Orange with Cucurbit[8]uril: Exchange and Release by Chemical Stimuli (dataset). https://doi.org/10.34804/supra.2021092814

Link: https://doi.org/10.34804/supra.2021092814
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

J. Mohanty, N. Thakur, S. Dutta Choudhury, N. Barooah, H. Pal, A. C. Bhasikuttan, J. Phys. Chem. B 2011, 116, 130–135.

Link: https://doi.org/10.1021/jp210432t%20
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Thiazole orange (3.3333333333333335e-11 M) and CB8 (0 — 6.666666666666667e-11 M).