Interaction

curated

Interaction Scheme

Molecule

Untitled
N6-Acetyllysine

c = 2000.0 µM

Host

Scx4
sCx4

c = 20000.0 — 300000.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 12.02 ± 34.0 M-1
Kd =
logKa = 1.08 ± NaN
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -6.16 ± NaN -1.47 ± NaN
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Nuclear Magnetic Resonance
Detailed information about the solvation.
Solvent System Buffer System 40 mM deuterated phosphate pD-7.4
Solvents Deuterium Oxide 100.0 %
Additives Disodium hydrog... 30.2 mM
Sodium dihydrog... 9.8 mM
Source of Concentration
Total concentration 40.0 mM
pH 7.4
Please find here information about the dataset this interaction is part of.
Citation:

K. D. Daze, F. Hof, C. S. Beshara, C. E. Jones, B. J. Lilgert, SupraBank 2024, A Simple Calixarene Recognizes Post-translationally Methylated Lysine (dataset). https://doi.org/10.34804/supra.2021092818

Link: https://doi.org/10.34804/supra.2021092818
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

C. S. Beshara, C. E. Jones, K. D. Daze, B. J. Lilgert, F. Hof, Chem. Eur. J. of Chem. Bio. 2009, 11, 63–66.

Link: https://doi.org/10.1002/cbic.200900633
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of N6-Acetyllysine (1.663893510815308 M) and sCx4 (0 — 3.327787021630616 M).