Interaction Scheme
Molecule
Amantadine
c = 0.0 — 4.42 µM
Host
CB7-HEG-BC
c = 1.0 µM
Binding Properties
| 𝜈 | Molecule 1 : 1 Host | ||
| Ka = | 2.75⋅107 | ± 1.96⋅106 | M-1 |
| Kd = | |||
| logKa = | |||
| T | 25.0 °C | ||
| Energy | kJ mol-1 | kcal mol-1 | |||
|---|---|---|---|---|---|
| ΔG | = | -42.47 | ± 0.18 | -10.15 | ± 0.04 |
These are the specifications of the determination of the experimental results.
| Detection Method: | Direct | |||
| Assay Type: | Direct Binding Assay | |||
| Technique: | Fluorescence | |||
| 𝛌ex | = | 350.0 nm | ||
| 𝛌em | = | 540.0 nm | ||
Detailed information about the solvation.
| Solvent System | Single Solvent |
| Solvent | water |
Please find here information about the dataset this interaction is part of.
| Citation: |
L. M. Grimm, F. Biedermann, C. Hu, A. Prabodh, A. Baksi, A. Siennicka, P. Levkin, M. Kappes, SupraBank 2025, Covalent cucurbit[7]uril–dye conjugates for sensing in aqueous saline media and biofluids (dataset). https://doi.org/10.34804/supra.20210928300 |
| Link: | https://doi.org/10.34804/supra.20210928300 |
| Export: | BibTex | RIS | EndNote |
Please find here information about the scholarly article describing the results derived from that data.
| Citation: |
C. Hu, L. Grimm, A. Prabodh, A. Baksi, A. Siennicka, P. A. Levkin, M. M. Kappes, F. Biedermann, Chem. Sci. 2020, 11, 11142–11153. |
| Link: | https://doi.org/10.1039/D0SC03079A |
| Export: | BibTex | RIS | EndNote | |
Binding Isotherm Simulations
The plot depicts the binding isotherm simulation of a 1:1 interaction of Amantadine (7.261561096293607e-07 M) and CB7-HEG-BC (0 — 1.4523122192587214e-06 M).
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