Interaction

uncurated

Interaction Scheme

Molecule

N retinylidine n ethanolamine
N-retinylidine-N-ethanolamine

c = 5.0 µM

Host

Beta cd
β-CD

c = 0.0 — 100000.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 250.0 M-1
Kd =
logKa = 2.4
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -13.69 -3.27
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Direct Binding Assay
Technique: Fluorescence
𝛌ex = 434.0 nm
𝛌em = 600.0 nm
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
Please find here information about the dataset this interaction is part of.
Citation:

M. M. Nociari, G. L. Lehmann, A. E. Perez Bay, R. A. Radu, Z. Jiang, S. Goicochea, R. Schreiner, J. D. Warren, J. Shan, S. Adam de Beaumais, M. Ménand, M. Sollogoub, F. R. Maxfield, E. Rodriguez-Boulan, SupraBank 2024, Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium (dataset). https://doi.org/10.34804/supra.20220628440

Link: https://doi.org/10.34804/supra.20220628440
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Please find here information about the scholarly article describing the results derived from that data.
Citation:

M. M. Nociari, G. L. Lehmann, A. E. Perez Bay, R. A. Radu, Z. Jiang, S. Goicochea, R. Schreiner, J. D. Warren, J. Shan, S. Adam de Beaumais, et al., Proceedings of the National Academy of Sciences 2014, 111, E1402–E1408.

Link: https://doi.org/10.1073/pnas.1400530111
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Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of N-retinylidine-N-ethanolamine (0.08 M) and β-CD (0 — 0.16 M).