Interaction

uncurated

Interaction Scheme

Molecule

Mvcp
MVCP

c = 0.0 — 2.25 µM

Host

Cb8
CB8

c = 1.13 µM

Indicator

Bc
Berberine chloride

c = 122.0 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 9.42⋅1012 ± 2.00⋅1011 M-1
Kd =
logKa = 12.97 ± 0.01
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -74.06 ± 0.05 -17.7 ± 0.01
These are the specifications of the determination of the experimental results.
Detection Method: Competitive
Assay Type: Competitive Binding Assay
Technique: Fluorescence
𝛌ex = 350.0 nm
𝛌em = 530.0 nm
Detailed information about the solvation.
Solvent System Single Solvent
Solvent water
Please find here information about the dataset this interaction is part of.
Citation:

L. Grimm, SupraBank 2024, Fluorescent Paracyclophanes: Unveiling Ultra-strong Binding with Cucurbit[8]uril in Aqueous Environments (dataset). https://doi.org/10.34804/supra.20240313527

Link: https://doi.org/10.34804/supra.20240313527
Export: BibTex | RIS | EndNote
Please find here information about the scholarly article describing the results derived from that data.
Citation:

Link: https://suprabank.org/datasets/527

Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of MVCP (2.1231422505307857e-12 M) and CB8 (0 — 4.246284501061571e-12 M).