Interaction

curated

Interaction Scheme

Molecule

Serotonin
Serotonin

c = 0.0 — 53.0 µM

Host

Ltl 001
Zeolite L3.0

0.15 wt%

Cofactor

Bdpp
BDPP

c = 4.9 µM

Binding Properties

𝜈 Molecule 1 : 1 Host
Ka = 1.00⋅106 ± 1.00⋅105 M-1
Kd =
logKa = 6.0 ± 0.04
T 25.0 °C ≈ 298 K
Energy kJ mol-1 kcal mol-1
ΔG = -34.25 ± 0.25 -8.19 ± 0.06
These are the specifications of the determination of the experimental results.
Detection Method: Direct
Assay Type: Associative Binding Assay
Technique: Fluorescence
𝛌ex = 300.0 nm
𝛌em = 519.0 nm
Detailed information about the solvation.
Solvent System Buffer System Neurobasal Medium, minus Phenol Red
Solvents water
Additives sodium chloride 69.0 mM
sodium bicabonate 26.0 mM
D-Glucose 25.0 mM
Hepes 11.0 mM
Source of Concentration
Total concentration 131.0 mM
pH 7.2
Suspension The parnter/host is present as a suspension.
Please find here information about the dataset this interaction is part of.
Citation:

L. M. Grimm, F. Biedermann, S. Sinn, M. Krstić, E. D'Este, I. Sonntag, E. A. Prasetyanto, T. Kuner, W. Wenzel, L. De Cola, SupraBank 2024, Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids (dataset). https://doi.org/10.34804/supra.20220323419

Link: https://doi.org/10.34804/supra.20220323419
Export: BibTex | RIS | EndNote
Please find here information about the scholarly article describing the results derived from that data.
Citation:

L. M. Grimm, S. Sinn, M. Krstić, E. D'Este, I. Sonntag, E. A. Prasetyanto, T. Kuner, W. Wenzel, L. De Cola, F. Biedermann, Adv. Mater. 2021, 33, 2104614.

Link: https://doi.org/10.1002/adma.202104614
Export: BibTex | RIS | EndNote

Binding Isotherm Simulations

The plot depicts the binding isotherm simulation of a 1:1 interaction of Serotonin (2.0e-05 M) and Zeolite L3.0 (0 — 4.0e-05 M).